论文部分内容阅读
将扶正化瘀方分为扶正组、化瘀组、虫草组、丹参组及丹参加虫草组,灌胃给药分离药物血清,观察各药物血清对大鼠肝星状细胞增殖、活化、型胶原和TGFβ1蛋白及其mRNA表达的影响。各组药物血清均可抑制星状细胞的增殖和活化,其中化瘀组效果最明显;各组药物血清均可抑制星状细胞型胶原mRNA及其蛋白的生成,以扶正组效果最佳;各组药物血清星状细胞TGFβ1mRNA及其蛋白生成均有明显的降低,以虫草组作用最强。
The Fuzheng Huayu Decoction was divided into Fuzheng group, Huayu group, Cordyceps group, Salvia miltiorrhiza group and Danjiao Cordyceps group. The drug serum was separated and administered by intragastric administration. The proliferation, activation and collagen of rat hepatic stellate cells were observed by each drug serum. And the effect of TGFβ1 protein and its mRNA expression. Each group of drug serum can inhibit the proliferation and activation of stellate cells, among which the Huayu group has the most obvious effect; each group of drug serum can inhibit the formation of stellate cell type collagen mRNA and protein, and the effect of the FENGZHENG group is the best; The serum levels of TGFβ1 mRNA and protein in serum of stellate cells in the group were all significantly decreased, and Cordyceps group had the strongest effect.