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[目的]了解嗜酸细胞性食管炎(EoE)的临床表现、内镜表现、病理学特点和诊治经验。[方法]回顾性分析2006-01—2016-01期间武汉第一医院收治的6例EoE患者的临床资料。[结果]EoE以吞咽困难、烧心等症状为主要表现;胃镜下可见食管黏膜糜烂、溃疡、水肿、狭窄,部分可见食管环;食管黏膜组织学检查可见大量嗜酸性粒细胞和肥大细胞浸润,细胞水肿和固有层纤维化。5例经脱敏和使用糖皮质激素治疗后均明显好转,1例经内镜下食管球囊扩张术联合糖皮质激素治疗效果满意,均随访1年以上无复发。[结论]EoE临床表现和内镜下表现无特异性,病理组织学检查对诊断EoE有重要价值,糖皮质激素是一线治疗用药。
[Objective] To understand the clinical manifestations, endoscopic findings, pathological features and diagnosis and treatment of eosinophilic esophagitis (EoE). [Methods] The clinical data of 6 patients with EoE admitted to Wuhan First Hospital from January 2006 to January 2016 were retrospectively analyzed. [Results] EoE was mainly manifested as dysphagia and heartburn. Esophageal mucosal erosion, ulcer, edema and stenosis were seen under endoscopy, esophageal ring was partially seen. Esophageal mucosa histology showed a large number of eosinophils and mast cells infiltration, Edema and lamina propria fibrosis. 5 patients after desensitization and glucocorticoid treatment were significantly improved in 1 case of endoscopic esophageal balloon dilatation combined with glucocorticoid treatment results were satisfactory, were followed up for more than 1 year without recurrence. [Conclusion] The clinical manifestations and endoscopic findings of EoE are nonspecific. Pathological examination is of great value in the diagnosis of EoE. Glucocorticoid is the first-line treatment.