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目的应用染色体核型分析技术,研究急性髓细胞白血病(AML)染色体改变与预后的关系。方法根据细胞遗传学改变,将214例初诊AML患者分为4组:伴t(15;17)改变患者为A组;伴t(8;21)/inv(16)改变患者为B组;正常核型及无其他组染色体改变为C组;伴t(9;22)或-7或复杂核型为D组,对各组患者进行预后分析。结果 214例AML患者染色体畸变率为57.01%。214例患者的平均生存时间为(13.16±8.497)月,A、B、C、D各组3年生存率分别为97.30%、86.36%、72.04%、47.5%,差异具有统计学意义(P值为0.001)。结论染色体是AML独立的预后因素,用于诊断及预后分析,有利于个体化治疗。
Objective To study the relationship between chromosomal changes and prognosis in acute myeloid leukemia (AML) using chromosome karyotype analysis. Methods According to cytogenetic changes, 214 newly diagnosed AML patients were divided into 4 groups: group A with t (15; 17) change; group B with t (8; 21) / inv (16) Karyotype and no other group of chromosome changes to C group; with t (9; 22) or -7 or complex karyotype D group, the prognosis of each group of patients. Results The chromosome aberration rate in 214 AML patients was 57.01%. The average survival time of 214 patients was (13.16 ± 8.497) months. The 3-year survival rates of A, B, C and D groups were 97.30%, 86.36%, 72.04% and 47.5%, respectively 0.001). Conclusion Chromosomes are independent prognostic factors of AML, which are useful for diagnosis and prognosis analysis and are beneficial to individualized treatment.