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目的 了解超广谱 β-内酰胺酶 (ESBL s)在肠杆菌科菌中的流行情况。方法 用双纸片协同法对临床送检各类标本中分离的 412株肠杆菌科菌进行 ESBL s检测。结果 ESBL s总检出率为 18.6 9% ,肠杆菌属、埃希菌属、沙雷菌属和克雷伯菌属菌 ESBL s的流行较严重 ,其 ESBL s检出率分别为 32 .2 6 %、2 9%、2 5 %和 2 0 .31% ,其次为枸橼酸杆菌属 (9.38% )、变形杆菌属 (6 .35 % )、沙门菌属 (5 .2 6 % )和志贺菌属 (4 .17% ) ;其中阴沟肠杆菌ESBL s检出率最高 ,达 46 .6 7% ,其次为大肠埃希菌 2 9%、液化沙雷菌 2 8.5 7%和粘质沙雷菌 2 8.5 7% ,深红沙雷菌、普里茅斯沙雷菌、聚团肠杆菌和臭鼻克雷伯菌 ESBL s检出率在 2 0 %～ 2 3.81%之间。结论 ESBL s在肠杆菌科菌中流行情况严重 ,分布面较广 ,以阴沟肠杆菌、大肠埃希菌、沙雷菌和克雷伯菌为主要流行菌株
Objective To understand the prevalence of extended spectrum β-lactamases (ESBLs) in Enterobacteriaceae. Methods ESBL s were tested on 412 strains of Enterobacteriaceae isolated from clinical specimens by double disc synergy method. Results The total detection rate of ESBLs was 18.6%. The prevalence of ESBLs in Enterobacter, Escherichia, Serratia and Klebsiella was more serious, and the detection rates of ESBLs were 32.2 6%, 29%, 25% and 20.31%, followed by Citrobacter (9.38%), Proteus (6.35%), Salmonella (5.26%) and Chi (4.17%). The detection rate of ESBLs in Enterobacter cloacae was the highest (46.67%), followed by Escherichia coli (29%), Serratia liquefacient (28.57%) and mucilage The detection rates of ESBLs of Klebsiella pneumoniae 2 8.5 7%, Serratia marcescens, Serratia marcescens, Enterobacter agglomerans and Klebsiella spp. Were between 20% ~ 23.81%. Conclusion The prevalence of ESBLs in Enterobacteriaceae is serious and has a wide distribution. The main epidemic strains are Enterobacter cloacae, Escherichia coli, Serratia and Klebsiella