血小板活化时，表面ＧＰⅡｂ／Ⅲａ受体变构，与纤维蛋白结合形成血栓．纤维蛋白识别ＧＰⅡｂ／Ⅲａ受体时，ＲＧＤ（Ａｒｇ－Ｇｌｙ－Ａｓｐ）是关键序列．含ＲＧＤ多肽可以竞争ＧＰⅡｂ／Ⅲａ受体，进而阻断血栓形成进程．作者注意到，含ＲＧＤ多肽的抗血栓活性与构象关系密切．采用Ｂｉｏｓｙｍ公司设计的Ｄｉｓｃｏｖｅｒ程序，计算了ＲＧＤＳ（Ａｒｇ－Ｇｌｙ－Ａｓｐ－Ｓｅｒ），ＲＧＤＶ（Ａｒｇ－Ｇｌｙ－Ａｓｐ－Ｖａｌ）和ＲＧＤＦ（Ａｒｇ－Ｇｌｙ－Ａｓｐ－Ｐｈｅ）在真空下、在水中和在正辛醇中的右手螺旋、左手螺旋及β伸展构象，讨论了构象对抗血栓活性的影响 Platelet activation, the surface of GP Ⅱ b / Ⅲ a receptor allosteric, fibrin and thrombosis. RGD (Arg-Gly-Asp) is the key sequence when fibrin recognizes GPⅡb / Ⅲa receptor. RGD-containing peptides can compete with GPIIb / IIIa receptors, thereby blocking the thrombosis process. The authors note that the antithrombotic activity of RGD-containing peptides is closely related to the conformation. RGDS (Arg-Gly-Asp-Ser), RGDV (Arg-Gly-Asp-Val) and RGDF (Arg-Gly-Asp-Phe) were calculated under vacuum in water using a Discover program designed by Biosym, Right-handed helix, left-handed helix, and beta-extension conformation in n-octanol, the effect of conformation on antithrombotic activity was discussed