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AIM: To investigate the efficacy and tolerability of albendazole and metranidazole treatment in giardiasis.METHODS: The open comparative randomized trial was carried out prospectively from_December 1999 to July 2001in Duzce City of Turkey. The diagnosis was based on the presence of signs and symptoms compatible with giardiasis including a positive stool examination of giardia cysts or trophozoite. Metranidazole group consisted of 29 patients and was given metranidazole 500 mg, three times a day for 5 d and albendazole group was consisted of 28 patients and was given albendazole 400 mg/d for 5 d.RESULTS: There were no significant differences in demographical and therapeutical effects and patient′s compliance between both groups. But side effects were seen more in metranidazole group than in albendazole group.CONCLUSION: Albendazole is as effective as metranidazole in adults′ giardiasis. Albendazole has less side effect potentials than metranidazole in the treatment of giardiasis.