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为了测定粘膜免疫肺炎球菌荚膜多糖(PS)是否能诱生粘膜和全身性免疫应答 ,及粘膜免疫是否能保护小鼠免受肺炎球菌致死性呼吸道感染 ,作者制备了包被 1 9型肺炎球菌 PS或 PS-霍乱毒素 B亚单位 (CTB)结合物 (PS- CTB)的藻酸盐微球 (AM)。 BAL B/c小鼠分别间隔两周口服 3次空A
To determine whether mucosal immunization of pneumococcal capsular polysaccharide (PS) induces mucosal and systemic immune responses and whether mucosal immunity protects mice from pneumococcal lethal respiratory infections, Alginate microspheres (AM) of PS or PS-cholera toxin B subunit (CTB) conjugate (PS-CTB). BAL B / c mice were orally administered 3 times a day, two weeks apart