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目的探讨静脉滴注利多卡因对结肠癌根治手术术后肠道功能恢复的临床效果。方法 40名择期结肠癌根治手术患者随机分为利多卡因组和对照组,每组20例。利多卡因组患者麻醉诱导前给予1.5 mg/kg利多卡因,继以2 mg/(kg·h)的速度静脉滴注至术后2 d,对照组给予同等体积的生理盐水。术中异氟醚吸入维持麻醉。术后舒芬太尼静脉患者自控镇痛。记录患者术后第一次排气、排便时间(小时)及达到出院标准的时间(天数)。结果两组患者年龄、性别比例及体重差异无统计学意义。利多卡因组和对照组患者术后首次排气时间分别为(57.2±12.5)h和(69.5±9.3)h,差异具有统计学意义(P<0.05);排便时间分别为(68.3±10.5)h和(77.6±11.1)h,两者差异具有统计学意义(P<0.05);达到出院标准的时间分别为(9.6±0.6)d和(11.4±0.8)d,差异具有统计学意义(P<0.05)。结论围术期静脉滴注小剂量利多卡因可明显促进结肠癌根治术患者术后肠道功能的恢复。
Objective To investigate the clinical effect of intravenous infusion of lidocaine on functional recovery of colon after radical operation of colon cancer. Methods Forty patients undergoing elective radical resection of colon cancer were randomly divided into lidocaine group and control group, with 20 cases in each group. The patients in lidocaine group were given lidocaine 1.5 mg / kg before induction of anesthesia, followed by intravenous infusion of 2 mg / (kg · h) 2 d after operation. The control group was given the same volume of saline. Intraoperative isoflurane inhalation to maintain anesthesia. Postoperative sufentanil intravenous patients with controlled analgesia. The patient’s first extubation, defecation time (hours), and time to discharge standard (days) were recorded. Results There was no significant difference in age, sex ratio and body weight between the two groups. The first postoperative exhaust time was (57.2 ± 12.5) h and (69.5 ± 9.3) h in the lidocaine group and the control group respectively, with statistical significance (P <0.05); the defecation times were (68.3 ± 10.5) h and (77.6 ± 11.1) h respectively, with statistical significance (P <0.05). The time to discharge standard was (9.6 ± 0.6) d and (11.4 ± 0.8) d, respectively, and the difference was statistically significant (P <0.05). Conclusion Perioperative intravenous infusion of low-dose lidocaine can significantly promote the recovery of postoperative intestinal function in patients with colon cancer.