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目的:探讨水蛭对血液流变学的影响。方法:采用钳夹颈总动脉的方法建立急性脑缺血缺血损伤模型。SD大鼠60只,随机分为4组,即观察(水蛭)组、对照(曲克芦丁)组、阳性对照组(造模不给药)、空白对照组。对观察组、对照组、阳性对照组造模后,分别给予观察组和对照组连续灌药20天。4组分别取标本后运用血液流变仪进行血液流变学各项指标的测定。结果:水蛭可以明显降低急性脑缺血大鼠的高、中、低切变率下的全血黏度、血浆黏度,减轻红细胞压积、降低纤维蛋白原浓度、抑制血小板聚集、增强红细胞变形能力。结论:水蛭可以显著降低急性脑缺血大鼠的血液黏度,改善血液浓、黏、凝、聚状态,其效果与西药曲克芦丁相当。
Objective: To investigate the effect of leech on hemorheology. Methods: Acute cerebral ischemic ischemic injury model was established by clamping the common carotid artery. Sixty SD rats were randomly divided into 4 groups: the observation group (Hydrazine), the control (Truekerudin) group, the positive control group (the model was not administered), and the blank control group. After the models were established in the observation group, the control group, and the positive control group, the observation group and the control group were respectively given potting for 20 days. After the specimens were taken from each of the 4 groups, blood rheometer was used to measure the indexes of hemorheology. RESULTS: Bletilla striata could significantly reduce the viscosity of whole blood and plasma in high-, medium-, and low-shear rates in rats with acute cerebral ischemia, reduce hematocrit, reduce fibrinogen concentration, inhibit platelet aggregation, and enhance red blood cell deformability. Conclusion: Bletilla striata can significantly reduce the blood viscosity of rats with acute cerebral ischemia and improve the state of blood concentration, viscosity, coagulation, and aggregation. The effect is similar to that of trochiturin.