The interaction effect of rotor wake on fuselage of helicopter was investigated with experimental method. The results from experiment have proved that for the drag of fuselage the effect of rotor airflow is closely in connection with both the flight speed and the collective pitch of blades, while for the thrust and pitch moment of fuselage the collective pitch angle of blades plays more important role. A simple and effective computing method about aerodynamic interaction can be derived from the measured data. In order to implement the experiment, a fuselage model, a special sensor, the measurement and data acquisition and processing system were designed and manufactured according to the special requirements of this research project, thereby a good base was built up for carrying out experiments successfully with high quality.