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目的:探讨血清透明质酸、转化生长因子β1(transforminggrowthfactor-β1,TGF-β1)与肝纤维化程度的关系。方法:检测116例慢性肝炎及肝硬化患者的血清透明质酸、TGF-β1水平,并与其中87例患者的肝组织病理结果作对照。结果:116例的血清透明质酸和TGF-β1水平与肝纤维化程度均呈中等程度正相关(r=0.584,r=0.612,P<0.001);以血清透明质酸和TGF-β1判别肝纤维化程度时,若将S1期、S2期、S3期不作区分,判别函数对推测S0期、S1～S3期和S4期的正确预测率为74.1%。结论:在估计肝纤维化程度时,宜同时检测血清透明质酸、TGF-β1水平,可推测慢性肝炎患者是“无肝纤维化”、“处于肝纤维化阶段”还是“肝硬化”,但不能精确估计肝纤维化的程度,故不能取代肝活检。
Objective: To investigate the relationship between serum hyaluronic acid, transforming growth factor β1 (TGF-β1) and hepatic fibrosis. Methods: The levels of serum hyaluronic acid and TGF-β1 in 116 patients with chronic hepatitis and cirrhosis were detected and compared with the pathological results of liver in 87 patients. Results: The levels of serum hyaluronic acid and TGF-β1 in 116 patients were moderately correlated with the degree of liver fibrosis (r = 0.584, r = 0.612, P <0.001). The levels of serum hyaluronic acid and TGF- When the degree of fibrosis, if S1, S2 and S3 are not distinguished, the correct predictive value of the discriminant function for estimating S0, S1 ~ S3 and S4 is 74.1%. Conclusions: In estimating the degree of hepatic fibrosis, it is advisable to detect the levels of hyaluronic acid and TGF-β1 at the same time. It can be inferred that patients with chronic hepatitis are “liver fibrosis”, “liver fibrosis stage” or “cirrhosis” Can not accurately estimate the extent of liver fibrosis, it can not replace the liver biopsy.