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目的:评价30年来国内中西医结合治疗强直性脊柱炎的疗效及安全性。方法:电子检索中国知识资源总库(CNKI)、万方学术期刊数据库、维普中文期刊数据库(VIP)、中国生物医学文献服务系统(CBM)等作为资料来源,检索时间均从建库至2011年12月。评价纳入研究的质量,用Revman5.1软件进行Meta分析。结果:共纳入31个随机对照试验,包括2629例患者。中西医结合总有效率要优于传统的改善病情抗风湿药,对Bath强直性脊柱炎疾病活动指数、Bath强直性脊柱炎功能指数、Bath强直性脊柱炎综合指数的改善有潜在优势。结论:仍需高质量的临床试验研究进一步验证中西医结合强直性脊柱炎的临床疗效和安全性.
Objective: To evaluate the efficacy and safety of Chinese traditional and western medicine in the treatment of ankylosing spondylitis in the past 30 years. Methods: CNKI, Wanfang Academic Periodical Database, VIP, Chinese CBM were searched electronically as search sources. The search time was from database construction to 2011 December. Assess the quality of the included studies and perform Meta-analysis using Revman 5.1 software. Results: A total of 31 RCTs were included, including 2629 patients. The total effective rate of traditional Chinese and Western medicine is better than the traditional disease-modifying antirheumatic drugs, which has the potential advantage to improve Bath ankylosing spondylitis disease activity index, Bath ankylosing spondylitis functional index and Bath ankylosing spondylitis comprehensive index. Conclusion: There is still a need for high-quality clinical trials to further validate the clinical efficacy and safety of Integrative Chinese and Western medicine in treating ankylosing spondylitis.