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[目的]发现含羟基类化合物中具有潜在修饰价值的抑菌先导化合物。[方法]采用菌丝生长速率法分别测定15种含羟基类化合物a~o对番茄灰霉病菌和烟草枯萎病菌的室内抑菌活性。[结果]初步构效关系表明化合物a~o对所测2种病原真菌均表现出不同程度的毒力,特别是α-萘酚(d)对番茄灰霉病菌和烟草枯萎病菌均表现出高于吧霉灵(o)的活性,其对应EC_(50)值分别为17.9、32.0mg/L和38.0、74.3mg/L。整体而言,化合物a、b和d~o对番茄灰霉病菌较烟草枯萎病菌敏感特别是化合物b、f和j,其番茄灰霉病菌的EC_(50)均低于烟草枯萎病菌EC_(50)值的10倍多。[结论]化合物a、b、f、g和I对番茄灰霉病菌均表现出较好的抑制活性,初步拟定将该5种化合物作为下一步开发抑菌剂的先导化合物。
[Objective] The research aimed to find the antibacterial lead compounds with potential modification value in hydroxyl-containing compounds. [Method] The mycelial growth rate method was used to determine the antibacterial activities of 15 hydroxyl-containing compounds a ~ o against Botrytis cinerea and Fusarium oxysporum f. [Result] The preliminary structure-activity relationship showed that compounds a ~ o showed different degrees of virulence to the two pathogenic fungi tested, especially α-naphthol (d) showed high to Botrytis cinerea and Fusarium oxysporum f. The activity of mold milieu (o), which corresponds to EC 50 values were 17.9,32.0 mg / L and 38.0,74.3 mg / L, respectively. Overall, the compounds a, b and d ~ o were more sensitive to Fusarium oxysporum than Fusarium oxysporum, especially to compounds b, f and j, and their EC50 of Botrytis cinerea were lower than that of Fusarium oxysporum f. More than 10 times the value. [Conclusion] The compounds a, b, f, g and I all showed good inhibitory activity against Botrytis cinerea, and the five compounds were preliminarily proposed as the lead compounds for further development of bacteriostatic agents.