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目的对比左氧氟沙星注射液与头孢曲松联合口服阿奇霉素治疗社区获得性下呼吸道感染的效果。方法选取本院2011年门诊收治92例社区获得性下呼吸道感染患者,其中实验组45例,采用左氧氟沙星注射治疗;对照组47例,采用头孢曲松联合阿奇霉素治疗。治疗时间为8~10 d,疗程结束后进行临床评价和细菌学结果分析。结果实验组有效率为86.7%,对照组有效率为85.1%;细菌杀除率实验组为92.9%,对照组为93.8%,差异无统计学意义(P>0.05)。患者中共发现11例非典型病原体感染,包括6例肺炎支原体和5例肺炎衣原体,经治疗后11例患者均痊愈。患者对两种治疗方法都表现出很好的耐受性。结论左氧氟沙星和头孢曲松联合阿奇霉素口服对治疗社区获得性下呼吸道感染有良好的疗效,是可靠的疗法。
Objective To compare the efficacy of oral levofloxacin and ceftriaxone in the treatment of community-acquired lower respiratory tract infections. Methods A total of 92 patients with community-acquired lower respiratory tract infection were enrolled in our clinic in 2011, of which 45 were in the experimental group and were treated with levofloxacin. In the control group, 47 patients were treated with ceftriaxone and azithromycin. Treatment time was 8 to 10 days. After the course of treatment, clinical evaluation and bacteriological results were analyzed. Results The effective rate was 86.7% in the experimental group and 85.1% in the control group. The bacterial elimination rate was 92.9% in the experimental group and 93.8% in the control group, with no significant difference (P> 0.05). Eleven patients with atypical pneumonia were found in the patient, including 6 cases of Mycoplasma pneumoniae and 5 cases of Chlamydia pneumoniae. All 11 patients recovered after treatment. Patients showed good tolerance to both treatments. Conclusion Levofloxacin and ceftriaxone combined azithromycin oral treatment of community-acquired lower respiratory tract infection has a good effect, is a reliable therapy.