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目的分析20年手足口病临床研究文献,归纳其证候、证素分布特点及常见证候与症状对应关系,以期为中医药辨证论治手足口病提供参考。方法以主题“手足口病”或者“手足口”和主题“中医”或者“证”作为检索词,从中国期刊全文数据库、维普期刊全文数据库、万方数据资源系统中检索文献,剔除不相关文献,运用Epidata 3.0软件建立规范数据库,运用SPSS 17.0软件对症状/体征、证候和证素出现的频次和频率进行统计分析和相关Logistic回归分析。结果普通型手足口病症状/体征频次较高的为皮疹、发热和纳差等。证候频次较高的是肺脾湿热证、湿热郁蒸证和邪犯肺卫证。证素方面,频次较高的病位是肺、脾、卫分;病性是湿热、热。Logistic回归分析,肺脾湿热证最可能的症状依次是口流涎、指纹紫;湿热郁蒸证最可能的症状依次是厚苔、壮热、指纹浓滞;邪犯肺卫证最可能的症状依次是鼻流涕、咳嗽。结论普通型手足口病最常见的证候类型是肺脾湿热证、湿热郁蒸证和邪犯肺卫证;手足口病常见的病位证素为肺、脾、卫分,常见的病性类证素为湿热、热。
Objective To analyze the literature about clinical research of hand-foot-mouth disease in 20 years and summarize its syndromes, the distribution characteristics of syndrome elements and the correspondence between common syndromes and symptoms, in order to provide a reference for the treatment of hand-foot-mouth disease. Methods Using the key words of “hand-foot-mouth disease” or “hand-foot-mouth” and the subject of “TCM” or “certificate” as the search term, the full-text database of Chinese periodicals, full text database of Vip Journals, Wanfang Data Resource System The documents were retrieved, the unrelated documents were excluded, and the normative database was established using Epidata 3.0 software. The frequency and frequency of symptoms / signs, syndromes and syndromes were analyzed by SPSS 17.0 software and related Logistic regression analysis. Results Common HFMD symptoms / signs were higher for rash, fever and anorexia. Syndrome frequency is higher spleen damp-heat syndrome, dampness Yu-steamed card and evil offensive lung card. In terms of syndromes, the higher frequency of the disease is lung, spleen, Wei points; pathogenicity is hot and humid. Logistic regression analysis showed that the most probable symptoms of spleen-damp-heat syndrome were oral salivation and fingerprinting. The most likely symptoms of damp-heat syndrome were followed by thick moss, strong heat and fingerprints; It is a runny nose, coughing. Conclusion The most common types of common hand, foot and mouth disease are syndromes of spleen and lung damp-heat syndrome, damp-heat syndrome and syndrome of evil lung. The common diseases of hand, foot and mouth disease are lung, spleen, Class certificate for the hot and humid, heat.