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用PCR-RLFP方法测定100名天津地区汉族正常人、134例Graves病(GD)患者的VDR-Fok1基因型,发现正常人与GD患者间VDR-Fok1基因型频率差异无统计学意义(P>0.05)。提示VDR-Fok1基因型不能作为预测中国汉族人发生GD危险性的遗传标志。
The genotypes of VDR-Fok1 in 100 normal Han patients and 134 Graves’ disease (GD) patients in Tianjin were detected by PCR-RLFP. There was no significant difference in the frequency of VDR-Fok1 between normal subjects and GD patients (P> 0.05). Suggesting that the VDR-Fok1 genotype can not be used as a genetic marker to predict GD risk in Chinese Han population.