目的了解南宁市吸毒人群HIV感染状况及高危行为情况。方法对南宁市戒毒所内戒毒者和社区吸毒者进行面对面行为学问卷调查。结果共调查379名吸毒者,检出HIV抗体阳性84人,阳性率22.2%;有共针史206人,占54.5%,最近1次共针率11.3%;与2005年的结果比下降明显(χ2=55.063,P=0.000),最近1个月共针率22%,与2005年同比下降明显(χ2=38.081,P=0.000)。吸毒者最近1次发生性行为时使用安全套比例27.1%,最近1次与临时性伴发生性关系时安全套使用率30.2%。结论南宁市针对静脉吸毒者的注射行为干预工作初见成效,共用针具的比例有所下降,但是,还应进一步降低无保护性行为的比例,加大高危性行为干预的力度。 Objective To understand HIV status and high-risk behavior among drug users in Nanning. Methods A questionnaire survey of face-to-face behavior was conducted among drug addicts and community addicts in Nanning Drug Abuser. Results A total of 379 drug addicts were detected, of which 84 were positive for HIV antibody, with a positive rate of 22.2%. There were 206 common acupuncture points (54.5%) and the last one was 11.3%. The results were significantly lower than those in 2005 χ2 = 55.063, P = 0.000). The rate of needling in the last month was 22%, which was significantly lower than that in 2005 (χ2 = 38.081, P = 0.000). The proportion of condoms used by the drug addicts during the most recent sexual intercourse was 27.1%. The most recent condom use was 30.2% when having sexual intercourse with temporary partners. Conclusions Nanning injection intervention for intravenous drug users has achieved initial success and the share of needle sharing has declined. However, the proportion of unprotected behavior should be further reduced and the intervention of high-risk sexual behaviors should be intensified.