前言自从一九四四年发现链霉素以来,到今天已经研制出许多氨基糖苷类药物。本类药物以它的强大的杀菌作用而具显著临床效果。但是,这些氨基糖苷类药物有一些缺点.其中有听觉器官毒性、肾毒性和神经肌肉阻滞等副作用。另外就是在体内动态方面安全区域狭窄。因此,在肾功能降低时,其用药方法是非常棘手的。 Introduction Since the discovery of streptomycin in 1944, many aminoglycosides have been developed to date. The class of drugs with its strong bactericidal effect and a significant clinical effect. However, these aminoglycosides have some disadvantages, including side effects such as auditory organ toxicity, nephrotoxicity and neuromuscular blockade. The other is the safety of the narrow area in vivo dynamics. Therefore, when the renal function is reduced, its method of treatment is very tricky.