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探讨中药石麦清液协同131I治疗Graves病(GD)的疗效及给药方法。GD患者100例随机分为A组:131I治疗,B组:131I+石麦清液治疗,服131I后7d服石麦清液20mL每天3次共40d。以治疗前和治疗后30d、90d测定血清FT3、FT4和TSH并选择8种症状,采用Kupperman四级评分评估。结果表明B组临床症状提前改善,安全渡过131I治疗一月后出现的FT3、FT4反跳性升高,A组30d后临床症状重于治疗前,FT3、FT4高于治疗前。B组90d临床症状显著改善,FT3、FT4和TSH测值正常,A组临床症状改善,但FT3、FT4低于正常,TSH高于正常。30d后B组安全渡过高危期,90d治疗后,减轻甲状腺功能减退症发病率疗效优于A组。石麦清液无毒性、安全和可在临床推广应用。
To investigate the efficacy and administration of traditional Chinese medicine Shimai Qing liquid in combination with 131I in the treatment of Graves disease (GD). 100 patients with GD were randomly divided into A group: 131I treatment, B group: 131I + stone wheat serum treatment, taking 131I 7d served stone clear liquid 20mL 3 times a day for 40 days. Serum FT3, FT4 and TSH were measured before treatment and 30d and 90d after treatment, and eight kinds of symptoms were selected and evaluated by Kupperman four-grade score. The results showed that the clinical symptoms of group B improved in advance, and the rebound of FT3 and FT4 increased after 131I treatment for one month. The clinical symptoms in group A were heavier than those before treatment and FT3 and FT4 were higher than those before treatment. The clinical symptoms of group B were significantly improved 90 days after operation. The values of FT3, FT4 and TSH were normal. The clinical symptoms of group A were improved. However, FT3 and FT4 were lower than normal and TSH was higher than normal. After 30 days, group B safely passed the high-risk period. After 90 days of treatment, the incidence of hypothyroidism was better than that of group A. Shek clear liquid non-toxic, safe and can be clinically applied.