目的:探讨联合检测抗环瓜氨酸肽抗体(CCP)和类风湿因子(RF)在早期诊断类风湿关节炎(RA)中的意义。方法:选取100例确诊RA患者作为研究对象(RA组),选取同期101例非RA患者作为参考对象(非RA组),抗CCP抗体采用酶联免疫吸附双抗体夹心法检测,RF采用速率散射比浊法检测,对比并分析检测结果。结果:RA组抗CCP阳性率79.00%(79/100)、RF阳性率75.00%明显高于非RA组抗CCP阳性率3.96%、RF阳性率25.74%,P<0.01;抗CCP抗体+RF敏感性85.00%、特异性97.03%明显优于RF敏感性75.00%和特异性74.26%,同时优于抗CCP抗体敏感性79.00%和特异性96.04%,P<0.01。结论:联合检测抗CCP抗体和RF能够提高RA诊断率,可弥补单独检测抗CCP抗体或RF的不足,为临床早期干预及阻断疾病进展提供参考依据,有效减少关节破坏和提高生存质量。 Objective: To explore the significance of combined detection of anti-cyclic citrullinated peptide antibody (CCP) and rheumatoid factor (RF) in the early diagnosis of rheumatoid arthritis (RA). Methods: A total of 100 patients with RA were enrolled in the study. One hundred and seventy non-RA patients were enrolled in this study (non-RA group). Anti-CCP antibody was detected by enzyme-linked immunosorbent assay (ELISA) Turbidimetric detection, comparison and analysis of test results. Results: The positive rate of anti-CCP in group RA was 79.00% (79/100), the positive rate of RF was 75.00%, which was significantly higher than that of non-RA group (3.96%) and the RF positive rate was 25.74% (P <0.01) 85.00% specificity and 97.03% specificity were significantly better than RF sensitivity 75.00% and specificity 74.26%, and also better than anti-CCP antibody 79.00% and specificity 96.04%, P <0.01. Conclusion: Combined detection of anti-CCP antibody and RF can improve the diagnosis rate of RA and make up for the deficiency of detecting anti-CCP antibody or RF alone. It can provide a reference for clinical intervention and blocking disease progression, effectively reduce joint destruction and improve quality of life.