【摘 要】
：
在羟基氮杂环化合物与卤代烃的无碱、专一性N-烷基化合成吡啶酮类化合物的反应中,N,N-二甲基甲酰胺(DMF)比其他溶剂具有更好的溶剂效应,使得该反应可以在更温和条件下得到更
【机 构】
：
温州大学化学与材料工程学院 浙江温州325035;扬州大学化学化工学院 江苏扬州225002;温州大学化学与材料工程学院 浙江温州325035;扬州大学化学化工学院 江苏扬州225002
论文部分内容阅读
在羟基氮杂环化合物与卤代烃的无碱、专一性N-烷基化合成吡啶酮类化合物的反应中,N,N-二甲基甲酰胺(DMF)比其他溶剂具有更好的溶剂效应,使得该反应可以在更温和条件下得到更高的收率,而且底物适用范围广.据机理研究和文献报道,除了一般的溶剂效应外,DMF还通过在反应中分解出二甲基胺作为碱促进反应进行.“,”In base-free specific N-alkylation of hydroxyl N-heterocycles with organohalides producing pyridone-type prod-ucts,N,N-dimethylformamide (DMF) was found to be the best solvent for having the most prominent solvent effect among the usual solvents.This not only led to milder reaction conditions and higher yields of the products,but also could broaden the substrate scope of the reaction.Mechanistic studies and the literature revealed that,in addition to the usual solvent effect,DMF can decompose to produce dimethylamine during the reaction,which then works as a base to promote the reaction.
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