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２－氧代－４－苯基丁基膦酸二甲酯（１）是Ｐｈａｒｍａｃｉａ公司研制开发的一个前列腺素类治疗青光眼的药物ｌａｔａｎｏｐｒｏｓｔ［１～４］的侧链，１的合成路线长，反应条件苛刻，收率偏低且原料难得。由于１的沸点较高（约１８０°Ｃ／０．０６７ｋＰａ［４］），高真?
Dimethyl 2-oxo-4-phenylbutylphosphonate (1) is a side chain of latanoprost [1 ~ 4], a prostaglandin-treated glaucoma drug developed by Pharmacia. The synthesis route of 1 is long, Harsh conditions, low yield and raw materials. Due to the higher boiling point of 1 (about 180 ° C / 0.067kPa [4]), high true