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用藻酸双酯钠(PSS)100mg每日3次口服30d一疗程,共治疗心血管病人31例。治疗前后用放免法测定血浆中TXB_2、6—酮—前列腺素F_(1a)的浓度变化,同时观察PSS对HDL—C、LDL—C胆固醇、出凝血时间、凝血酶元时间的影响。发现PSS对TXB_2有明显的降低作用,对6酮——前列腺素F_(1a)值的变化治疗前后相差显著。PSS对LDL胆固醇的降低作用明显,对HDL胆固醇的升高作用不明显,两者比值治疗前后相差显著。对出凝血时间、凝血酶元时间均无影响。提示PSS对动脉粥样硬化有预防和治疗作用,且无明显副作用。
100 mg of sodium alginate (PSS) was given 3 times a day for 30 days and a total of 31 patients were treated for cardiovascular disease. Before and after treatment, radioimmunoassay was used to determine the concentration of TXB_2 and 6-keto-prostaglandin F_(1a) in plasma. At the same time, the effects of PSS on HDL-C, LDL-C cholesterol, coagulation time and prothrombin time were observed. It was found that PSS had a markedly reduced effect on TXB 2 , and there was a significant difference between before and after treatment of changes in the value of 6-keto-prostaglandin F_(1a). The effect of PSS on the reduction of LDL cholesterol was significant, and the effect on the increase of HDL cholesterol was not obvious. The difference between the two values before and after treatment was significant. There was no effect on coagulation time or thrombin time. It is suggested that PSS has preventive and therapeutic effects on atherosclerosis without obvious side effects.