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目的探讨米非司酮配伍米索前列醇用于中期妊娠的临床效果。方法回顾我院近3年使用米非司酮配伍米索前列醇于中期妊娠要求终止妊娠的病例(78例)作为观察组和运用依沙吖啶行中期妊娠引产的病例(57例)作为对照组,比较两组的宫缩发动时间、总产程时间、产后出血量及引产成功例数。结果两组宫缩发动时间及总产程差异均有统计学意义,观察组产程明显小于对照组,但两组对终止中期妊娠的成功率差异无统计学意义。结论米非司酮配伍米索前列醇用于中期妊娠引产具有用药方便、损伤小、毒副作用少,值得临床推广,可以替代羊膜腔注射依沙吖啶作为终止中期妊娠的首选方法。
Objective To investigate the clinical effect of mifepristone and misoprostol for mid-term pregnancy. Methods A retrospective review was conducted in the past three years in our hospital with mifepristone and misoprostol for termination of pregnancy in the second trimester of pregnancy (78 cases) as the observation group and the use of ethacridine midwifery induction of labor (57 cases) as a control Group, compared the two groups of contractions start time, total labor time, postpartum hemorrhage and induction of labor cases. Results The two groups had significant differences in the time of onset of contractions and the total duration of labor between the two groups. However, there was no significant difference between the two groups in the success rate of termination of the second trimester pregnancy. Conclusion Mifepristone combined with misoprostol for induction of labor in the second trimester has the advantages of convenient administration, less damage and less side effects. It is worthy of clinical promotion. It can replace amniotic fluid injection of Ethacridine as the first choice of termination of mid-term pregnancy.