Objective To release the heroin addicts sufferings,we made rapid opiate detoxification by injecting naloxine under the general anesthesia. Method 160 volunteers were divided at random into two groups:Group A were performed under the combined anesthesia with propofol, midazolam and ketamine,Group B were performed under the combined anesthesia with propofol with midazolam and tramadol. The vital signs were recorded and the withdrawal syndrome of the volunteers were assessed during the whole process.Result All of the withdrawal symptoms scores 24 hours after ROD in group B were lower than its pre-treatment;The symptoms of the thirst, sleeping disturbance,nausea and vomiting,skeletal muscular pains and anorexia scores in group A were also lower than its pre-treatment;and no too much difference between group A and group B.But tearing,anxiety and diarrhea scores in group A were almost the same as the pre-treatment and higher than group B.Both groups received of the naloxone treatment smoothly,and remained in the hospital for about 3 days. Conclusion The effect of rapid opiate detoxification of naltrexone with the ketamine or tramadol under anesthesia is obvious. The tramadol is better than others.