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目的探讨双侧原发性乳腺癌的临床特征及其危险因素。方法 30例双侧原发性乳腺癌患者作为观察组,其中异时性双侧原发性乳腺癌19例(观察A组),同时性双侧原发性乳腺癌11例(观察B组);随机选取同期收治的57例单侧原发性乳腺癌患者作为对照组。回顾分析两组患者的临床资料。结果观察组发病年龄、月经初潮年龄显著低于对照组,差异有统计学意义(P<0.05)。观察组第一原发癌确诊时的绝经率显著低于对照组,乳腺癌家族史阳性率显著高于对照组,差异有统计学意义(P<0.05)。观察组第一原发癌同侧腋窝淋巴结转移阳性率与对照组相比差异无统计学意义(P>0.05)。观察A组与对照组术后放疗治疗率相比差异无统计学意义(P>0.05)。观察A组第一原发癌与第二原发癌在同一镜影象限阳性率显著低于观察B组,差异有统计学意义(P<0.05)。结论与单侧原发性乳腺癌相比,双侧原发性乳腺癌的发病年龄更低、乳腺癌家族史更明显,雌激素与双侧原发性乳腺癌的发生发展可能有着某种密切的关系。
Objective To investigate the clinical features and risk factors of bilateral primary breast cancer. Methods Thirty patients with bilateral primary breast cancer served as observation group, including 19 cases of synchronous bilateral primary breast cancer (group A) and 11 cases of bilateral primary breast cancer (group B) 57 patients with unilateral primary breast cancer were randomly selected as the control group. Retrospective analysis of two groups of patients clinical data. Results The onset age and the age of menarche in observation group were significantly lower than those in control group (P <0.05). The rate of the first primary cancer in the observation group was significantly lower than that in the control group at diagnosis, and the positive rate of family history of breast cancer was significantly higher than that in the control group (P <0.05). The positive rates of ipsilateral axillary lymph node metastasis in the first primary cancer group were not significantly different from those in the control group (P> 0.05). There was no significant difference between the two groups (P> 0.05). The positive rate of the first primary cancer and the second primary cancer in the same mirror in group A was significantly lower than that in observation group B, the difference was statistically significant (P <0.05). Conclusion Compared with unilateral primary breast cancer, the incidence of bilateral primary breast cancer is lower, and the family history of breast cancer is more obvious. The occurrence and development of estrogen and bilateral primary breast cancer may be closely related Relationship.