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目的:讨论高同型半胱氨酸水平增高与老年人静脉血栓栓塞症的关系。方法:对19例确诊有下肢静脉血栓的老年患者,用高效液相色谱法测定血浆同型半胱氨酸的水平,设年龄、性别匹配的正常对照组20例。结果:下肢静脉血栓组的同型半胱氨酸水平高于正常对照组(P<0.05),静脉血栓患者中34.1%血浆同型半胱氨酸水平升高,高同型半胱氨酸使静脉血栓发生的相对危险性增加2.44倍,且随着年龄增长呈指数增加,故老龄可作为静脉血栓栓塞的独立危险因素。结论:老年人血浆中同型半胱氨酸的升高是静脉血栓形成的一个危险因素。
OBJECTIVE: To discuss the relationship between elevated homocysteine levels and venous thromboembolism in the elderly. Methods: Twenty-nine elderly patients with confirmed venous thrombosis of the lower extremity were examined for plasma homocysteine levels by high performance liquid chromatography (LC-MS / MS). Twenty patients were selected as normal control group. Results: Homocysteine levels in lower extremity venous thrombosis group were significantly higher than those in normal control group (P <0.05), 34.1% plasma homocysteine level increased in patients with venous thrombosis, and high homocysteine caused venous thrombosis Relative risk increased 2.44 times, and with age increased exponentially, so aging can be used as an independent risk factor for venous thromboembolism. Conclusion: Elevated plasma homocysteine in the elderly is a risk factor for venous thrombosis.