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目的:探讨模拟65 msw饱和潜水暴露对机体氧化应激的影响。方法:7名健康男性潜水员参加65 msw饱和潜水,在暴露前、中、后取24 h尿检测超氧化物歧化酶(SOD)、丙二醛(MDA)、总氨基酸(T-AA)、总抗氧化能力(T-AOC)含量,同时监测24 h尿量及体重变化。结果:总氨基酸含量在减压末期比基础值显著增高,减压后1周恢复至正常水平;SOD、MDA、T-AOC在各时间点无明显变化。进舱后第1天尿量比进舱前基础值明显减少,随后逐渐恢复。加压后第2天开始体重逐渐增高,减压结束时比进舱前体重明显增高。结论:模拟65 msw饱和潜水暴露未造成参试潜水员明显氧化损伤。在饱和潜水试验中实时监测24 h尿量及氧化应激程度对防止机体损伤具有重要意义。
OBJECTIVE: To investigate the effect of simulating a 65-msec saturated-diving exposure on oxidative stress in the body. Methods: Seven healthy male divers participated in a saturated submersible with a mean time of 65 ms. The urine samples were taken for 24 h before, during and after exposure to detect the content of superoxide dismutase (SOD), malondialdehyde (MDA), total amino acid (T-AA) Antioxidant capacity (T-AOC) content, while monitoring 24 h urine output and weight changes. Results: The content of total amino acid in the end of decompression was significantly higher than the basal value, and returned to normal level one week after decompression. There was no significant change of SOD, MDA and T-AOC at all time points. On the first day after entering the urine volume than before entering the base value decreased significantly, and then gradually recovered. Body weight gradually increased on the second day after pressurization, and the weight at the end of decompression was significantly higher than that before entering the capsule. CONCLUSIONS: Simulated 65-ms-w saturated scuba diving did not cause significant oxidative damage to test divers. Real-time monitoring of 24-hour urine output and the degree of oxidative stress in saturated diving tests is of great importance to prevent body damage.