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目的探讨HBV阳性原发性肝癌(HCC)与血清HBV-DNA水平、饮酒史及性别因素的关系。方法回顾性分析浙江大学医学院附属第一医院2005年1月至2007年7月住院的HBV阳性HCC401例和同期住院的慢乙肝(CHB)患者401例,采用以年龄为配比变量的1:1匹配的病例对照研究,将HBsAg、HBeAg、HBcAb阳性分为大三阳组,HBsAg、HBeAb、HBcAb阳性分为小三阳组。结果计量资料采用配对t检验,计数资料采用Pearson卡方检验,结果提示不管是大三阳组还是小三阳组,HBV DNA水平、饮酒史和性别均与HCC有关系;Logistic回归分析HBV DNA、饮酒史和性别与HCC的关系,同样提示HBV DNA水平、饮酒史和性别与HCC的发病有关系。结论HBV DNA水平、性别和饮酒史在HBV阳性的原发性肝癌的发生中占重要作用,对HBV DNA高水平的男性饮酒患者,更应建议戒酒并采取合适的抗病毒治疗方案,并加强监测随访,降低肝癌的发生率或及早发现肝癌。
Objective To investigate the relationship between HBV positive primary liver cancer (HCC) and serum HBV-DNA levels, drinking history and gender factors. Methods A retrospective analysis of 401 cases of HBV positive HCC hospitalized in the First Affiliated Hospital of Zhejiang University Medical College from January 2005 to July 2007 and 401 cases of chronic hepatitis B (CHB) patients hospitalized in the same period, using age-matched variables 1: In a matched case-control study, HBsAg, HBeAg, and HBcAb were positively divided into three positive groups, and HBsAg, HBeAb, and HBcAb were positively divided into small three positive groups. The results of measurement data using paired t test, count data using Pearson chi-square test, the results suggest that regardless of the big three positive group or Xiaosanyang group, HBV DNA levels, drinking history and gender are related to HCC; Logistic regression analysis of HBV DNA, drinking The relationship between history and gender and HCC also suggests that HBV DNA levels, drinking history, and gender are related to the onset of HCC. Conclusion The level of HBV DNA, gender and drinking history play an important role in the occurrence of HBV-positive primary hepatocellular carcinoma. For men with high levels of HBV DNA drinking, it is recommended to abstain from alcohol and take appropriate antiviral treatment regimen. Follow-up monitoring, reduce the incidence of liver cancer or early detection of liver cancer.