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在印度阿萨姆米基尔丘陵区的6个茶园,以血检无性恶性疟原虫阳性者56例为对象,分为2组,每组28例。第1组用氯喹三天疗法,成人第1天和第2天服药(基质)各600毫克,第3天300毫克,每天剂量作一次顿服。第2组每天口服硫酸奎宁一次,剂量为1克,连服5天,并在服奎宁的头3天每天口服乙胺嘧啶一次,剂量为50毫克。在氯喹组开始服药后的1～3天用Wilson和Ede-son试验测定尿内氯喹排泄量的结果表明,氯喹的吸收和同化作用都很好。按世界卫生组织鉴定抗药性的方法,对氯喹组的25例从
Six tea plantations in the Assam Mir district in India were divided into two groups (n = 28 in each group). Fifty-six were positive for blood clotting asexual Plasmodium falciparum. The first group with chloroquine three days therapy, adult day 1 and 2 days of medication (matrix) of each 600 mg, 300 mg on the 3rd day, day dose for Dayton clothing. Group 2 daily oral administration of quinine sulfate, a dose of 1 g, and even served 5 days, and in the first three days of taking quinine oral pyrimethamine once daily dose of 50 mg. The results of Wilson’s and Ede-son tests for the determination of urinary chloroquine excretion 1 to 3 days after starting the administration of chloroquine showed that the absorption and assimilation of chloroquine were good. According to the method of WHO identification of drug resistance, 25 cases of chloroquine group from