短链脂肪酸(SCFAs)是膳食纤维结肠腔内经细菌发酵的产物,提供的能量约占人体总能量的5%～15%。SCFA不尽是肠上皮细胞重要的能量来源,还可影响影响肠粘膜屏障,肠上皮细胞的通透性、氧化应激反应等,对结肠功能和健康具有重要的作用。但是也有一些动物和体外研究表明,较高浓度的SCFAs对结肠的渗透性和敏感性有负面影响。 Short chain fatty acids (SCFAs) are the product of bacterial fermentation in the colonic cavity of dietary fibers and provide about 5% to 15% of the total body energy. SCFA is not an important source of energy for intestinal epithelial cells, but also affect the intestinal mucosal barrier, the permeability of intestinal epithelial cells, oxidative stress response, plays an important role in colon function and health. However, some animal and in vitro studies have shown that higher concentrations of SCFAs have a negative effect on colon permeability and sensitivity.