论文部分内容阅读
目的：探讨了急性肾炎患儿治疗前后血清IL-2，IL-18和 TNFα水平的变化及临床意义。方法应用放射免疫分析法和免疫化学法对33例急性肾炎患儿进行了治疗前后血清IL-2，IL-18和 TNFα水平检测，并与35名正常健康儿作比较。结果急性肾炎患者在治疗前血清IL-2水平非常显著地低于正常人（p<0.01），而血清IL-18， TNFα水平又非常显著地高于正常人组（p0.05），且血清IL-2水平与IL-18， TNFα水平呈显著负相关（r=-0.4928，-0.5134，p<0.01）。结论检测急性肾炎患儿血清IL-2，IL-18和 TNFα水平的变化对观察病情和预后判定均具有重要的临床价值。“,”objective: To explore the changes of serum IL-2,IL-18 and TNFα levels after treatment in pediatric patients with acute Nephritis . Methods: serum IL-2,TNF2 (with RIA) serum IL-18 (with immune chemistry )levels in 33 pediatric patients with acute nephritis both before and after treatment as wel as in 35 controls . Results: Before treatment, the serum IL-2 level was significantly . Cower in the patients than those in the controls (p0.05),Serum IL-2 levels was negatively correlated with serum IL-18 ,TNFα levels (r=-0.4928,-0.5134,p<0.01). Conclusions: Detection of serum IL-2, IL-18 and TNFα levels after treatment might be of prognostic values in patients with acute nephritis .