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慢性肝病时铜和锌的代谢慢性肝病时微量元素的代谢发生一系列异常,但主要表现为血锌降低、血铜升高、血铁降低;肝锌降低、肝铜增加;以及尿锌和尿铜增加等。锌1939年Patek 和Haig 就注意到某些肝硬化患者的夜盲症不能用维生素A 改善;1959年Valee 首先描述了酒精性肝硬化患者锌代谢异常,病人表现为血锌、肝锌降低,而尿锌则反常地升高;1970年
Metabolism of Copper and Zinc in Chronic Liver Diseases A series of abnormalities occur in the metabolism of trace elements in chronic liver disease, but the main manifestations are reduced blood zinc, elevated blood copper, decreased blood iron, decreased liver zinc, increased liver copper, and urinary zinc and urine Copper increase and so on. Zinc In 1939, Patek and Haig noticed that night blindness in some patients with cirrhosis was not improved by vitamin A. In 1959 Valee first described the abnormal metabolism of zinc in patients with alcoholic cirrhosis. The patients showed serum zinc and hepatic zinc, while urinary zinc Then abnormally increased; 1970 years