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质子泵抑制剂(PPI)的应用使内科治疗胃食管返流疾病有了显著的改变,但长期应用存在安全性和费用问题,手术仍为治疗复杂的胃食管返流疾病(狭窄和严重食管炎)的另一种选择。 材料和方法:用Markov模式来比较糜烂性食管炎病人的内科与手术治疗。随访100013例病人达5年,每3个月为一阶段,计20个循环。两种治疗方案为:(1)应用奥美拉唑达到愈合和维持的目的;(2)用腹腔镜行Nissen胃底折叠术
The use of proton pump inhibitors (PPIs) has led to a significant change in medical treatment of gastroesophageal reflux disease, but safety and cost problems exist in long-term use, and surgery is still complicated by the treatment of gastroesophageal reflux disease (stenosis and severe esophagitis ) Another option. Materials and Methods: Markov model was used to compare the medical and surgical treatment of patients with esophageal erosions. The follow-up of 100013 patients for 5 years, every 3 months for a period of 20 cycles. The two treatment options are: (1) the purpose of the application of omeprazole for healing and maintenance; (2) laparoscopic Nissen fundoplication