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六条在心脏上装有高精度压力传感器及微型超声测距探头的慢性实验狗,经两个星期的手术恢复期后,于Halothane麻醉下,给予低氧气体吸入,使动脉血氧饱和度从对照时的99.8±0.1％降到60.7-4.4％。低氧时,左心室功能随着动脉血氧饱和度的下降,表现为中度低氧时增强、严重低氧时减弱的变化。复氧时,出现与低氧时不相同的左心室功能异常,如心动过速、严重心律紊乱、后负荷增高、舒张期末室壁厚度显著增加,室壁舒-缩厚度差减小、室壁舒缩的不匀质性以及极低的心肌顺应性等。这些结果表明,在急性低氧后的复氧过程中,左心室功能存在着一种“复氧损伤”。
Six chronic experimental dogs with a high-precision pressure sensor and a miniature ultrasonic distance-measuring probe on the heart were given inhalation of hypoxic gas under Halothane anesthesia for two weeks after the operative recovery period to bring arterial oxygen saturation from control Of 99.8 ± 0.1% down to 60.7-4.4%. Hypoxia, left ventricular function with arterial oxygen saturation decreased, showed moderate hypoxia increased, severe hypoxia, weakened changes. During reoxygenation, left ventricular dysfunction, such as tachycardia, severe heart rhythm disorder, increased afterload, increased wall thickness at end diastole, decreased systolic-systolic wall thickness, Shrinkage of the heterogeneity and low myocardial compliance. These results suggest that there is a “reoxygenation injury” in left ventricular function during reoxygenation following acute hypoxia.