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目的探讨白细胞介素-6(IL-6)和超敏C-反应蛋白(hs-CRP)的血浆水平在监测冠心病病情方面的作用及与冠状动脉病变程度的关系。方法冠心病患者80例,按临床诊断分为急性心肌梗死(AMI)组30例、不稳定型心绞痛(UAP)组30例、稳定型心绞痛(SAP)组20例,对照组20例。测定(IL-6)、hs-CRP的水平,比较各组间的差异。结果 AMI组、UAP组及SAP组的IL-6和hs-CRP水平均比对照组高,差异有统计学意义(P<0.05);AMI组、UAP组和SAP组IL-6和hs-CRP水平相比,差异有统计学意义(P<0.05);AMI组与UAP组IL-6和hs-CRP水平相比,差异有统计学意义(P<0.05);IL-6和hs-CRP水平变化呈正相关。结论血浆IL-6和hs-CRP可能是冠状动脉粥样硬化的标志,参与了冠心病的发病过程,其数值与冠状动脉病变程度密切相关。
Objective To investigate the role of plasma levels of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) in the monitoring of coronary heart disease and its relationship with the severity of coronary artery disease. Methods Eighty patients with coronary heart disease were divided into three groups according to clinical diagnosis: 30 cases of AMI group, 30 cases of unstable angina pectoris group, 20 cases of stable angina pectoris group and 20 cases of control group. The levels of IL-6 and hs-CRP were measured and the differences between groups were compared. Results The levels of IL-6 and hs-CRP in AMI, UAP and SAP groups were significantly higher than those in control group (P <0.05). IL-6 and hs-CRP (P <0.05). The levels of IL-6 and hs-CRP in AMI group and UAP group were significantly higher than those in UAP group (P <0.05). The levels of IL-6 and hs-CRP Changes were positively correlated. Conclusions Plasma IL-6 and hs-CRP may be markers of coronary atherosclerosis, which is involved in the pathogenesis of coronary heart disease. The values are closely related to the severity of coronary artery disease.