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目的探讨血清超敏C-反应蛋白、白介素-6与老年冠心病患者肺炎衣原体感染的相关性,探讨冠心病的可能致病机制,为诊断和治疗提供参考依据。方法选取2013年4月-2013年12月冠心病患者57例及同期健康体检者60名分别作为观察组和对照组,采集两组人员空腹静脉血行实验室检查,并进行比较,采用SPSS13.0软件进行统计分析。结果观察组IgG滴度及阳性率为1.70±0.28及84.21%、对照组为1.51±0.22及48.33%,两组比较差异有统计学意义(P<0.05),观察组患者TNF-α、IL-6、hsCRP以及Fg水平均明显高于对照组,两组比较差异有统计学意义(P<0.05);观察组IgG阳性患者TNF-α、hsCRP以及Fg水平均明显高于阴性者,二者比较差异有统计学意义(P<0.05)。结论肺炎衣原体感染与冠心病发生和发展有一定的相关性,对感染肺炎衣原体的冠心病患者检测血清hsCRP及IL-6水平,可以早期诊断、提高患者的治疗效果。
Objective To investigate the correlation between serum high-sensitivity C-reactive protein, interleukin-6 and Chlamydia pneumoniae infection in elderly patients with coronary heart disease and to explore the possible pathogenesis of coronary heart disease and to provide a reference for diagnosis and treatment. Methods From April 2013 to December 2013, 57 patients with coronary heart disease and 60 healthy people at the same period were selected as the observation group and the control group respectively. The fasting venous blood samples of two groups were collected and compared by SPSS 13.0 Software for statistical analysis. Results The titer and positive rate of IgG in the observation group were 1.70 ± 0.28 and 84.21%, and those in the control group were 1.51 ± 0.22 and 48.33%, respectively. There was significant difference between the two groups (P <0.05) 6, hsCRP and Fg levels were significantly higher than the control group, the difference between the two groups was statistically significant (P <0.05); the observed group of IgG-positive patients TNF-α, hsCRP and Fg levels were significantly higher than the negative The difference was statistically significant (P <0.05). Conclusions Chlamydia pneumoniae infection has some correlation with the occurrence and development of coronary heart disease. Detecting serum hsCRP and IL-6 levels in CHD patients with CHD can make early diagnosis and improve the therapeutic effect.