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本文通过测定胎盘及胎鼠体内氯乙烯单体(VCM)的含量及胎肝嗜多染红细胞微核出现率,研究了VCM经胎盘转运及其对胎仔体细胞的致突变作用。结果表明:VCM可通过小鼠胎盘,并与染毒浓度和妊期有关,胎盘对VCM的转运有一定的屏障作用。停止接触17小时后胎仔体内不再能检出VCM。5000ppm染毒组微核出现率显著高于对照组,说明高浓度VCM可通过胎盘使胎仔体细胞出现染色体损伤。
In this paper, the placental transport of VCM and its mutagenic effects on fetal somatic cells were studied by measuring the content of VCM and the occurrence of micronuclei in fetal liver. The results showed that VCM could pass through the placenta of mice and was related to the exposure concentration and pregnancy duration. The placenta had certain barrier function to VCM transport. VCM can no longer be detected in the fetus after 17 hours of contact. The incidence of micronuclei in 5000ppm exposure group was significantly higher than that in control group, indicating that high concentrations of VCM can cause chromosome damage in fetal somatic cells through the placenta.