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目的探讨炎前细胞因子水平变化对儿童急性感染性腹泻患儿诊断的临床意义。方法2006年1月至2007年12月,采用ELISA方法测定183例急性感染性腹泻患儿炎前细胞因子白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、白介素8(IL-8)水平,并与32名健康儿童对照组进行比较。结果入院时无论是细菌性肠炎还是病毒性肠炎,炎前细胞因子均高于对照组,炎前细胞因子参与了儿童急性感染性腹泻的致病过程;当病情好转,进入恢复期时血清炎前细胞因子水平又趋于正常。结论临床可依炎前细胞因子水平的及时、准确地快速检测来观察儿童急性感染性腹泻病情的阶段,有针对性地取有效的治疗措施,并且有助于了解患儿病情及免疫状况。
Objective To investigate the clinical significance of pre-inflammatory cytokines levels in the diagnosis of children with acute infectious diarrhea. Methods From January 2006 to December 2007, the levels of interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-6) in 183 children with acute infectious diarrhea were detected by ELISA. 8), and compared with 32 healthy children control group. Results At admission, either bacterial enteritis or viral enteritis, pre-inflammatory cytokines were higher than the control group, pre-inflammatory cytokines involved in the pathogenesis of acute infectious diarrhea in children; when the condition improved, into the recovery period before serum inflammation Cytokine levels turn normal again. Conclusions The clinical stage of acute infectious diarrhea in children can be observed quickly, accurately and rapidly by the pre-inflammatory cytokines level. Targeted measures can be taken and the condition and immune status of children can be understood.