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目的：探讨以Castleman病组织学特征为主要表现的Hodgkin病的病理学特点及两者之间的关系。方法：对1例以Castleman病组织学特征为主要表现的Hodgkin病进行了光镜、免疫组织化学及原位分子杂交的观察。结果：淋巴结组织内淋巴滤泡明显增生．淋巴滤泡生发中心大小正常或较小，部分滤泡中心网状细胞增生，小淋巴细胞围绕滤泡呈套状排列似洋葱皮样结构，滤泡间及副皮质区见有明显增生的血管，部分血管壁增厚并有透明样变，滤泡之间及副皮质区见有较多的Hodgkin细胞及Reed-Stenberg细胞，CD15、CD30免疫组化染色阳性。结论：诊断为Castlemani病但不久又复发的患者，除仔细复查第一次活检切片并重新活检外，还应做免疫组织化学或原位分子杂交检测病毒DNA，有助于对Hodgkin细胞及Reed－Sternberg细胞识别，提高Hodgkin病的正确诊断，避免再次出现漏诊。
OBJECTIVE: To investigate the pathological features of Hodgkin’s disease and its relationship with the histological features of Castleman’s disease. Methods: One case of Hodgkin ’s disease characterized by histopathological features of Castleman’ s disease was observed by light microscopy, immunohistochemistry and in situ hybridization. Results: Lymphoid follicles significantly proliferated in lymph nodes. Lymphatic follicles germinal center size normal or small, part of the follicular center reticular cells hyperplasia, small lymphocytes arranged in folds around the follicles like onion skin-like structure, follicular and paracortical area to see obvious hyperplasia of blood vessels, Some of the vascular wall thickening and transparent change, between the follicles and the paracortex area to see more Hodgkin cells and Reed-Stenberg cells, CD15, CD30 immunohistochemical staining. CONCLUSIONS: Patients diagnosed with Castlemani disease but relapsed shortly thereafter, in addition to careful review of the first biopsy and subsequent biopsy, should be immunohistochemically or in situ hybridized to detect viral DNA, which may be of benefit to Hodgkin cells and Reed- Sternberg cell recognition improves the correct diagnosis of Hodgkin’s disease and avoids missed diagnosis again.