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目的观察固尔苏联合鼻塞型气道正压通气(CPAP)治疗新生儿呼吸窘迫综合征(NRDS)的临床疗效,探讨其临床应用价值。方法选取本院2010年3月至2011年10月新生儿科收治的呼吸窘迫综合征患儿56例,采用随机分组法分为对照组(28例)与观察组(28例),对照组患者单纯采用鼻塞型气道正压通气治疗,观察组患者采用鼻塞型气道正压通气联合小剂量固尔苏气管内滴注,观察并比较两组患者治疗前后血气、血氧合指数变化、并发症发生情况及临床总有效率。结果两组患儿治疗后PaO2、PaCO2及PaO2/FiO2较治疗前均有明显改变,比较具有统计学意义(P<0.05),且治疗后观察组患者各项指标与对照组比较也具有显著性差异(P<0.05);治疗后患者出现肺炎、肺出血、颅内出血及动脉导管未闭等并发症,其中观察组患儿并发症的发生率明显高于对照组,临床总有效率为89.29%,明显高于对照组(53.57%),两组比较差异显著,具有统计学意义(P<0.05)。结论小剂量固尔苏联合鼻塞型气道正压通气(CPAP)治疗新生儿呼吸窘迫综合征(NRDS)疗效显著,值得临床推广和应用。
Objective To observe the clinical efficacy of Gul-Su-Su combined with nasal-filled positive airway pressure (CPAP) in the treatment of neonatal respiratory distress syndrome (NRDS), and to explore its clinical value. Methods Fifty-six children with respiratory distress syndrome admitted to neonatology department from March 2010 to October 2011 were randomly divided into control group (n = 28) and observation group (n = 28). Patients in the control group Nasal obstruction type positive airway pressure was used to treat the patients in the observation group. The patients in the observation group were treated with nasal obstruction type airway pressure ventilation combined with small dose of celestose with tracheal intratracheal instillation. The changes of blood gas and oxygenation index and complication Occurrence and total clinical efficiency. Results The PaO2, PaCO2 and PaO2 / FiO2 in both groups after treatment were significantly changed compared with those before treatment (P <0.05). After treatment, the indexes in the observation group were also significant compared with the control group (P <0.05) .Pneumonitis, pulmonary hemorrhage, intracranial hemorrhage, patent ductus arteriosus and other complications occurred in the patients after treatment. The incidence of complications in the observation group was significantly higher than that in the control group, with a total clinical effective rate of 89.29% , Which was significantly higher than that of the control group (53.57%). There was significant difference between the two groups (P <0.05). Conclusion Small dose of Coult-Su and nasal obstruction positive airway pressure (CPAP) treatment of neonatal respiratory distress syndrome (NRDS) significant effect, it is worthy of clinical promotion and application.