在慢性乙肝病毒感染过程中 ,淋巴细胞向受病毒感染肝组织的迁移、浸润 ,对于抗病毒免疫应答及炎症反应的发生起着决定性作用。而对其机理的研究尚未取得令人满意的答案。近年来 ,对趋化因子与其受体的相互作用的研究表明 ,激活的淋巴细胞可表达特定的受体分子 ,并受相应趋化因 In the process of chronic hepatitis B virus infection, the migration and infiltration of lymphocytes into the virus-infected liver tissue play a decisive role in antiviral immune response and inflammatory response. However, the study of its mechanism has not yet achieved a satisfactory answer. In recent years, studies on the interaction of chemokines with their receptors have shown that activated lymphocytes express specific receptor molecules and are regulated by the corresponding chemokines