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目的 探讨慢性肾功能不全各个阶段糖尿病与非糖尿病患者骨形成指标的异同。方法 采用放免法和常规生化检测法。结果 血浆全段甲状旁腺素水平在非糖尿病肾衰患者中显著升高 ,氮质血症期和尿毒症期分别达到正常值上限的 2倍和 3 .5倍 ;在糖尿病肾衰患者中仅尿毒症期偏高 ,为正常值上限的 1.6倍。血碱性磷酸酶和骨钙素水平也随肾功能减退而上升 ,但糖尿病组和非糖尿病组之间无显著性差异。结论 在慢性肾衰不同阶段 ,糖尿病患者继发性甲状旁腺机能亢进无非糖尿病组显著 ,其骨转换率较非糖尿病组为低
Objective To explore the similarities and differences of bone formation indexes between diabetic and non-diabetic patients in all stages of chronic renal insufficiency. Methods Radiotherapy and routine biochemical detection method. Results The plasma total parathyroid hormone levels in non-diabetic patients with renal failure increased significantly, azotemia and uremia were up to 2 times the upper limit of normal and 3.5 times; in patients with diabetic renal failure only Uremia period is high, 1.6 times the upper limit of normal. Blood alkaline phosphatase and osteocalcin levels also increased with renal dysfunction, but there was no significant difference between diabetic and non-diabetic groups. Conclusion In different stages of chronic renal failure, secondary hyperparathyroidism in diabetic patients is significantly higher than that in non-diabetic patients, and its bone turnover rate is lower than non-diabetic patients