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目的:探讨血清超敏C反应蛋白(hs-CRP)、血浆活化蛋白C抵抗(APCR)与妊娠期高血压疾病(HDCP)的相关性,为HDCP的诊治提供客观依据。方法:选择2010年1月~2012年12月该院产科收治的200例HDCP患者作为观察组,其中妊娠期高血压71例,子痫前期轻度62例,子痫前期重度67例,并随机选择同期的正常孕晚期孕妇70例作为对照组,比较各组患者血清hs-CRP水平以及血浆APCR阳性率差异。结果:观察组血清hs-CRP水平〔(6.49±5.12)mg/L〕明显高于对照组〔(2.18±2.28)mg/L〕,差异有统计学意义(P<0.05),且观察组患者随着病情加重,血清hs-CRP水平逐渐升高,差异有统计学意义(P<0.05)。观察组血浆APCR阳性率为35.50%(71/200),对照组血浆APCR阳性率为7.14%(5/70),观察组明显高于对照组,差异有统计学意义(P<0.05);观察组不同病情血浆APCR阳性率差异有统计学意义(P<0.05)。结论:清清hs-CRP和血浆APCR与HDCP均有密切关系,密切监测两者变化,对HDCP的预防、诊断和治疗有重要价值。
Objective: To investigate the correlation between serum hs-CRP, APCR and HDCP, and to provide an objective basis for the diagnosis and treatment of HDCP. Methods: 200 HDCP patients admitted from January 2010 to December 2012 in our hospital were selected as the observation group. Among them, 71 cases of gestational hypertension, 62 cases of mild preeclampsia and 67 cases of severe preeclampsia were selected and randomized Seventy pregnant women of the same period of the third trimester of pregnancy were selected as the control group, and the difference of serum hs-CRP level and plasma APCR positive rate was compared between the two groups. Results: The level of hs-CRP in the observation group 〔(6.49 ± 5.12) mg / L〕 was significantly higher than that in the control group 〔(2.18 ± 2.28) mg / L〕, the difference was statistically significant (P0.05) As the disease progressed, serum hs-CRP levels gradually increased, the difference was statistically significant (P <0.05). The positive rate of APCR in the observation group was 35.50% (71/200), while the positive rate of APCR in the control group was 7.14% (5/70). The observation group was significantly higher than that of the control group (P <0.05) There were significant differences in the positive rate of APCR in different groups (P <0.05). Conclusion: There is a close relationship between the clearance of hs-CRP and plasma APCR and HDCP. Close monitoring of the changes of both hs-CRP and plasma APCR has important value in the prevention, diagnosis and treatment of HDCP.