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目的 研究胃癌患者的生存期与个性特征、应付方式等心理因素 ,以及免疫功能的关系。方法 对胃癌晚期患者 (胃癌Ⅰ组 )、胃癌较长生存期患者 (胃癌Ⅱ组 )及正常健康人 (对照组 )分别进行明尼苏达多相个性测验 (MMPI)、应对方式问卷 (CSQ)、免疫功能测试 ,并做相关分析。结果(1)MMPI:胃癌Ⅱ组人格障碍评分 (42 0± 10 5 )及社会内向评分 (42 2± 11 6 ) ,低于其他两组 [胃癌Ⅰ组为 (49 3± 11 2 )分和 (48 3± 9 4)分 ,对照组为 (48 6± 10 9)分和 (39 9± 11 5 )分 ;P均 <0 0 5 ];(2 )CSQ :解决问题和求助因子分 ,胃癌Ⅰ组 [分别为 (0 6 8± 0 2 7)分和 (0 42± 0 18)分 ]均低于胃癌Ⅱ组[分别为 (0 82± 0 18)分和 (0 6 5± 0 2 1)分 ;P <0 0 5和P <0 0 1],胃癌Ⅱ组更多采取成熟的应对方式 ;(3)自然杀伤细胞 (NK细胞 ) :胃癌Ⅱ组水平 (2 1 4± 9 2 )高于胃癌Ⅰ组 [(14 2± 8 8) ;P <0 0 5 ];而NK细胞水平与MMPI的抑郁 (r =- 0 35 )、人格障碍 (r=- 0 39)、偏执 (r =- 0 2 9)、精神衰弱 (r =- 0 30 )及精神分裂 (r=- 0 30 )等量表呈负相关 ,与CSQ的解决问题因子 (r =0 35 )及应付方式类型(r=0 34)呈正相关。结论 与胃癌Ⅰ组比较 ,胃癌Ⅱ组更为外向 ,负性情绪较少 ,更多采取成熟
Objective To study the relationship between the survival time, personality characteristics, coping style and other psychological factors and immune function in patients with gastric cancer. Methods MMPI, CSQ, immune function were performed in patients with advanced gastric cancer (gastric cancer group I), patients with long-term survival of gastric cancer (gastric cancer II group) and normal healthy subjects (control group). Test and do relevant analysis. Results (1) MMPI: gastric cancer II group personality disorder score (42 0 ± 10 5) and social introversion score (42 2 ± 11 6), lower than the other two groups [gastric cancer group I was (49 3 ± 11 2) points and (48 3 ± 9 4) points for the control group (48 6 ± 10 9) points and (39 9 ± 11 5) points; P all < 0 0 5 ]; (2) CSQ: problem solving and help seeking factors, Gastric cancer group I [(0.68 ± 0.77) points and (0.42 ± 0.018) points, respectively] were lower than those in gastric cancer group II [(0.82 ± 0.018) points and (0.65 ± 0, respectively). 2 1) points; P <0 0 5 and P <0 01, gastric cancer group II more mature coping style; (3) natural killer cells (NK cells): gastric cancer group II level (2 1 4 ± 9 2) higher than gastric cancer I group [(14 2 ± 8 8); P <0 0 5]; and NK cell level and MMPI depression (r = - 0 35), personality disorder (r = - 0 39), paranoia (r =- 0 2 9), mental debility (r =- 30) and schizophrenia (r = -30) are negatively correlated, and CSQ is a problem-solving factor (r = 0.35) and coping methods Type (r=0 34) is positively correlated. Conclusion Compared with gastric cancer group I, gastric cancer group II is more outward-facing, with less negative emotions and more mature