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目的探讨血清肿瘤坏死因子α(TNF-α)、胰岛素样生长因子1(IGF-1)水平的变化与多囊卵巢综合征(PCOS)发病的关系。方法采集90例PCOS病人和41例正常人血清,应用酶联免疫吸附试验(ELISA)方法检测两组TNF-αI、GF-1的表达水平。结果PCOS病人血清TNF-α及IGF-1的表达水平明显高于对照组,差异有显著性(t=32.341、3.986,P<0.01);TNF-α含量与PCOS病人是否肥胖有关(t=21.760,P<0.01);PCOS病人血清TNF-α水平与IGF-1的含量呈正相关关系(r=0.74,P<0.05);正常对照组血清TNF-α水平与IGF-1的含量无明显相关性(P>0.05)。结论TNF-αI、GF-1水平升高可能与PCOS的发病有关。
Objective To investigate the relationship between the changes of serum tumor necrosis factor-α (TNF-α) and insulin-like growth factor 1 (IGF-1) levels and the pathogenesis of polycystic ovary syndrome (PCOS). Methods Ninety serum samples from patients with PCOS and 41 normal controls were collected. The expressions of TNF-αI and GF-1 in the two groups were detected by enzyme linked immunosorbent assay (ELISA). Results The serum levels of TNF-α and IGF-1 in PCOS patients were significantly higher than those in control group (t = 32.341, 3.986, P <0.01) , P <0.01). There was a positive correlation between the level of serum TNF-α and the level of IGF-1 in PCOS patients (r = 0.74, P <0.05). There was no significant correlation between the levels of serum TNF- (P> 0.05). Conclusions The elevated levels of TNF-αI and GF-1 may be related to the pathogenesis of PCOS.