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目的探讨替吉奥化疗联合三维适形放射治疗中晚期食管癌的临床疗效。方法选取2011年1月—2014年1月于福建医科大学附属泉州第一医院收治的中晚期食管癌患者60例,按照随机数字表法分为对照组和观察组,每组30例。对照组患者采取三维适形放疗方案进行治疗,观察组患者在对照组基础上联合替吉奥化疗。比较两组患者的近期疗效、毒副作用(恶心呕吐、腹泻、口腔炎、脱发)。随访3年,统计比较两组患者1年生存率、2年生存率、3年生存率及生存质量评分。结果观察组患者客观缓解率高于对照组(P<0.05)。观察组患者恶心呕吐、腹泻、口腔炎、脱发发生率均低于对照组(P<0.05)。两组患者2年生存率、3年生存率相近,差异无统计学意义(P>0.05),观察组患者1年生存率高于对照组(P<0.05)。观察组患者躯体健康、心理健康、社会功能、物质生活评分高于对照组(P<0.05)。结论采用替吉奥化疗联合三维适形放疗治疗中晚期食管癌的近期疗效明显,可有效延缓患者肿瘤进展,减少毒副作用,有利于改善患者的生存质量。
Objective To investigate the clinical efficacy of tegaserod combined with three-dimensional conformal radiotherapy for advanced esophageal cancer. Methods Sixty patients with advanced esophageal cancer who were admitted to Quanzhou First Hospital, Fujian Medical University from January 2011 to January 2014 were divided into control group and observation group according to random number table method, with 30 cases in each group. Patients in the control group were treated with three-dimensional conformal radiotherapy. The patients in the observation group were treated with tirofiban on the basis of the control group. The short-term efficacy, side effects (nausea, vomiting, diarrhea, stomatitis and hair loss) of the two groups were compared. The patients were followed up for 3 years, and the 1-year survival rate, 2-year survival rate, 3-year survival rate and quality of life score were compared statistically. Results The observation group objective response rate was higher than the control group (P <0.05). The incidence of nausea and vomiting, diarrhea, stomatitis and hair loss in the observation group were lower than those in the control group (P <0.05). The 2-year survival rate and 3-year survival rate were similar between the two groups (P> 0.05). The 1-year survival rate in the observation group was higher than that in the control group (P <0.05). Observation group patients physical health, mental health, social function, physical life score higher than the control group (P <0.05). Conclusion The treatment of advanced esophageal cancer with TIGO combined with three-dimensional conformal radiotherapy has obvious curative effect in the short term, which can effectively delay the progress of the tumor, reduce the side effects and improve the quality of life of the patients.