4-表-道克萨红菌素4-epi-DX 是道克萨红菌素(doxorubicin)的一种新的类似物。动物实验证明,它与道克萨红菌素一样具有广泛的抗肿瘤形成活性。它对人体肿瘤的裸鼠移植物也有抑制作用,其中包括黑色素瘤、乳腺癌、燕麦细胞肺癌、前列腺癌和卵巢癌.然而,4-epi-DX 仍有一定的毒副作用,尤以脱发为常见.为降低这种药物的毒副作用,本研究旨在探讨联合应用4-表-道克萨红菌素+5-氟尿嘧啶的可能性. 4-Table-Doxorubicin 4-epi-DX is a new analog of doxorubicin. Animal experiments have shown that it has broad anti-tumor activity like doxorubicin. It also has inhibitory effects on human tumor xenografts in nude mice, including melanoma, breast cancer, oat cell lung cancer, prostate cancer, and ovarian cancer. However, 4-epi-DX still has some toxic side effects, especially hair loss. In order to reduce the toxic and side effects of this drug, the present study was designed to investigate the possibility of combined use of 4-epi-oxacin + 5-fluorouracil.