【摘 要】
:
Glycyrrhetinic acid (GA) is the bioactive ingredient in Giycyrrhizae Radix et Rhizoma.Our previous study has reported that GA has protective effect on realgar-induced bepatotoxicity.However,the details of the hepatoprotective mechanisms of GA on realgar-i
【机 构】
:
Department of Health Laboratory Technology, School of Public Health, China Medical University, Sheny
论文部分内容阅读
Glycyrrhetinic acid (GA) is the bioactive ingredient in Giycyrrhizae Radix et Rhizoma.Our previous study has reported that GA has protective effect on realgar-induced bepatotoxicity.However,the details of the hepatoprotective mechanisms of GA on realgar-induced liver injury remain to be elucidated.In the study,mice were divided into control,GA-control,realgar,and co-treated groups.Their liver tissues were used for metabonomics study by ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) method.The results illustrate that GA significantly ameliorate the liver injury and metabolic perturbations caused by realgar.Some metabolites,such as phenylalanine,pyroglutamic acid (PGA),proline,carnitine,nicotinamide,choline,lysophosphatidylcholine (LPC) 16:0 and LPC 18:2 were found responsible for the hepatoprotective effect of GA.These metabolites are associated with the methylation metabolism of arsenic,cell membrane structure,energy metabolism and oxidative stress.From the results of this study,we infer that the potential hepatoprotective mechanism of GA on realgar-induced liver injury may be associated with reducing arsenic accumulation and its methylation metabolism in the liver,promoting the conjugation of arsenic and GSH to play detoxifieation effect,and ameliorating the liver metabolic perturbations caused by realgar.
其他文献
Neuropathic pain (NP) has become a serious global health issue and a huge clinical challenge without available effective treatment.P2 receptors family is involved in pain transmission and represents a promising target for pharmacological intervention.Trad
Glioblastoma is the deadliest neoplasm with the worst 5-year survival rate among all human cancers.Autophagy promotes autophagic cell death or blocks the induction of apoptosis in eukaryotic cells.Here,we investigated whether varying levels of autophagie
Fructus Psoraleae,which is commonly consumed for the treatment of osteoporosis,bone fracture,and leucoderma,induces liver injury.This study investigated the pathogenesis of the ethanol extract of Fructus Psoraleae (EEFP)-induced liver injury in rats.EEFP
Penicildiones A-D (1-4),four new steroids derivatives together with three known compounds including 16α-methyl-pregna-17α,19-dihydroxy-(9,11)-epoxy-4-ene-3,18-dione-20-acetoxy (5),stachybotrylactone B (6) and stachybotrin (7) were isolated from the soft c
Lonicerae Japonicae Flos (LJF),a kind of traditional Chinese medicines (TCMs),has functions of detoxifying and evacuating heat.In the study,a method based on ultra-high performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrome
Mycosphazine A (1),a new iron(Ⅲ) chelator of coprogen-type siderophore,and mycosphamide A (2),a new cyclic amide benzoate,together with six known aryl amides (3-8),were isolated from the fermentation broth of the deep-sea-derived fungus Mycosphaerella sp.
With the occurrence of aging process,decreased neuron dopamine,disrupted brown adipose tissue (BAT) remodeling and decreased butyrate level all reflect a weak host healthy in certain degree.Nevertheless,the signs of mid-adult gut microbiota,and its associ
Given the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies,the discovery of novel and effective therapeutic targets have been in an urgent demand.Recent studies have revealed that long noneoding RNAs (lncRNAs) pla