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目的:观察血栓通注射液联合低分子肝素治疗肾病综合征的疗效。方法:将100例患者随机分为对照组和治疗组,每组50例。对照组采用低分子肝素;治疗组采用血栓通注射液联合低分子肝素。两组疗程均为4周,分别测定治疗前后的临床疗效、24小时尿蛋白定量、血清白蛋白、血脂、血液流变学以及肾功能改善的情况。结果:临床疗效比较,治疗组显效率72%,总有效率92%,对照组显效率40%,总有效率65%,(P<0.05)。生化指标比较治疗组24小时尿蛋白定量明显降低,血清白蛋白明显升高,肾功能有所改善,*P<0.05,**P<0.01。治疗组血液TG(三酰甘油)、Ch(总胆固醇)均有不同程度的下降(P<0.01)、HDL(高密度脂蛋白)升高较对照组明显(P<0.01)治疗组全血比粘度、血浆比粘度、血细胞比容、纤维蛋白原治疗前后效果明显,其中降低纤维蛋白原幅度大,作用快。与对照组比较,经t检验有显著差异(P<0.05)。结论:血栓通注射液联合低分子肝素治疗肾病综合征的疗效肯定。
Objective: To observe the effect of Xueshuantong injection combined with low molecular weight heparin on nephrotic syndrome. Methods: 100 patients were randomly divided into control group and treatment group, 50 cases in each group. The control group with low molecular weight heparin; the treatment group with thrombosis injection combined with low molecular weight heparin. The two groups were treated for 4 weeks, respectively, before and after treatment to determine the clinical efficacy, 24-hour urine protein, serum albumin, blood lipids, hemorheology and renal function improved. Results: Compared with the control group, the effective rate of the treatment group was 72% and the total effective rate was 92%. The effective rate of the control group was 40% and the total effective rate was 65% (P <0.05). Compared with the biochemical indexes, the 24-hour urinary protein in the treatment group was significantly lower, serum albumin was significantly increased, renal function was improved, * P <0.05, ** P <0.01. TG and triglyceride decreased (P <0.01) and HDL (HDL) increased significantly in the treatment group compared with the control group (P <0.01). The ratio of whole blood in the treatment group Viscosity, plasma specific viscosity, hematocrit, fibrinogen effect before and after treatment significantly, which reduce the amplitude of fibrinogen, fast. Compared with the control group, t test showed significant difference (P <0.05). Conclusion: Xueshuantong injection combined with low molecular weight heparin in the treatment of nephrotic syndrome is sure.